C57BL/6 - Wikipedia
WEBC57BL/6, often referred to as "C57 black 6", "B6", "C57" or "black 6", is a common inbred strain of laboratory mouse. It is the most widely used "genetic background" for genetically modified mice for use as models of human disease.
000664 - B6 Strain Details - The Jackson Laboratory
WEBC57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis.
C57BL/6 Mice | Charles River - Charles River Laboratories
WEBThe C57BL/6 mouse is a multipurpose model that can be used for research into physiology, immunology, safety and efficacy, oncology and genetics, as well as mouse model creation. B6 mice are often preferred to other inbred mice in certain research disciplines such as metabolic research.
The History of Black 6 Mice | Charles River Laboratories
WEBThe History of Black 6 Mice. How one mouse strain aided a century of drug discovery. The timeline: 1921: Geneticist C.C. Little inbred the first C57BL mice from specimens reared by breeder Abby Lathrop. 1937: Strain 6 was separated out from the C57BL colony, becoming the C57BL/6 or “black 6” strain.
All Black 6 mice are not created equal - The Jackson Laboratory
WEBThe C57BL/6J mouse is one of the most versatile laboratory mice. It is protected from genetic drift by a unique, patented Genetic Stability Program. You may wonder what the key differences are between C57BL/6J and C57BL/6N and when one substrain is a more appropriate choice than the other.
WEBGenetic Management of C57BL/6 Mouse Colony. Inbred strains are defined as animals produced by a minimum of 20 generations of brother-sister mating, traceable to a single founding pair. Individuals of an inbred strain are genetically uniform, also …
How The B6 Mouse Strain is Revolutionising Drug Discovery
WEBOct 2, 2017 · Inbred mice are critical tools in biomedical research and one particular strain, known as C57BL/6 (Black 6 or B6, for short), is rapidly becoming the standard model for many applications and revolutionising modern research.
The genome of Eve (the mouse) - The Jackson Laboratory
WEBC57BL/6 (commonly called Black 6) mice are the most widely used strain used in research. When researchers began working to sequence the mouse genome 20 years ago, Black 6 was chosen to supply it. Specifically, C57BL/6J …
WEBThe C57BL/6 mouse is a multipurpose model that can be used in such fields as model creation, physiology, safety and efficacy and genetics. General Purpose – Atochina, E.N. et al. Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization.
Protect Your Research: Know Your B6 Mouse - The Jackson …
WEBApr 13, 2020 · The C57BL/6 inbred mouse (B6) is the most commonly used research strain. This strain is the most well characterized, the first to have its’ entire genome sequenced, and is the genetic background strain of …