The Sweet 16 has begun, and the biggest question right now is how USC can survive tougher competition without star guard JuJu Watkins. The sophomore left the court after injuring her right leg against Mississippi Sate, and tests revealed an ACL tear in her right knee.

Ole Miss vs Michigan State, Kentucky vs Tennessee, Michigan vs Auburn, Purdue vs Houston Sweet 16 NCAA Tournament game predictions, picks today.

The Auburn Tigers take on the Michigan Wolverines in a Sweet 16 matchup in the 2025 NCAA Men's Basketball Tournament on Friday, March 28.

With Auburn's season on the brink, Tahaad Pettiford and Denver Jones suddenly became unstoppable. On to the Elite Eight for the top overall seed in the NCAA Tournament. Pettitford and Jones scored 20 points apiece to lead a second-half barrage that rallied the Tigers to a 78-65 victory over Michigan in the Sweet 16 on Friday night.

Friday night, No. 1 seed Houston looked at risk of another disappointing Sweet 16 exit.  But the Cougars found their stroke to start the second half and held on for a thrilling 62-60 win over No. 4 Purdue thanks to a perfectly executed inbounds play that resulted in Milos Uzan's game-winning layup with 0.

The No. 1 Houston Cougars and No. 4 Purdue Boilermakers round out the Sweet 16 on Friday night at Lucas Oil Stadium in Indianapolis, Indiana.

The second Sweet 16 matchup in Regional 1 Spokane of the 2025 NCAA Women’s Basketball Tournament sees the 1 seed UCLA Bruins going against the 5 seed Ole Miss Rebels at Spokane Arena in Spokane, Wash. on Friday, March 28.

Nothing like a conference rivalry matchup to instantly turn up the heat in the Sweet 16. Duke and UNC split their two games this season, each winning at home. The Tar Heels’ victory was a low-scoring overtime affair, 53-46, as only two of the 20 total players reached double figures.