Our AutoCAR CRISPR/Cas12a activation scheme employs a specially designed small DNA nanostructure termed “Cir-mediator” comprising a double strand (dsDNA) and a ssDNA region (Fig. 1B). The dsDNA region ...
A DNA-tethered force-sensing platform delivers calibrated piconewton forces directly to Piezo1, revealing an activation threshold of about 15 pN independent of membrane tension, enabling precise, ...
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