Polycystic kidney disease (PKD) causes round, fluid-filled sacs called cysts to grow in your kidneys. These cysts can cause your kidneys to enlarge and function poorly. People with PKD can also ...

PKD is mainly caused by mutations in the PKD1 and PKD2 genes, affecting polycystin proteins. Disrupted signaling pathways, like cAMP and vasopressin, are major drivers of cyst growth. Tolvaptan is ...

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Fibroblast growth factor 23 (FGF-23) levels, which have been shown previously to be elevated in adults with autosomal polycystic kidney disease (ADPKD), are elevated early in the course of the disease ...

Chronic kidney disease (CKD) is extremely prevalent among adults, affecting over 800 million individuals worldwide. Many of these patients eventually require therapy to supplement or replace kidney ...

The retrospective, single-centre design may have introduced selection bias and limited generalisability. The reliance on clinical echocardiographic reports could have led to interobserver variability, ...

Liver cysts were found in over 80% of patients with ADPKD but were not associated with chronic kidney disease stage, Mayo classification, PKD1 or PKD2 genotype variant, liver enzyme levels, or quality ...

When I was 16, I was in a car accident on my way to school and my spleen was injured. I needed to undergo a CT scan to make sure there was no other internal damage to my organs. The ER doctors checked ...