In particular, type III interferons appeared to play a crucial role in the mucosal antiviral immunity of Egyptian fruit bats: After infection with a variety of zoonotic viruses, bat organoids ...

Innate immunity serves as the first line of host defense against microbial infections. Development of antiviral innate immunity involves induction of type I interferons (IFNs), which is triggered ...

More information: Zixuan Wang et al, Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity, Proceedings of the National Academy of Sciences (2025 ...

New antiviral response discovered in mammals Date: October 10, 2013 Source: ETH Zurich Summary: Researchers have discovered a part of the innate immune system in mice that had only been known in ...

Insects possess a remarkable ability to develop innate immune memory, and the mechanisms underlying this process are becoming a central topic in innate immunity research.

Unlocking the secrets of bat immunity Organoids unveil new defense mechanisms against zoonotic viruses Date: May 21, 2025 Source: Helmholtz Centre for Infection Research ...

Trained immunity in alveolar macrophages can lead to damaging lung inflammation, confirming the importance of context in this phenomenon.

The innate immune system provides the first line of defense against viruses and bacteria, quickly producing a variety of anti-viral and proinflammatory proteins to fend off infection while the ...

“ Pre-infection antiviral innate immunity contributes to sex differences in SARS-CoV-2 infection,” by Natalie Sauerwald, Zijun Zhang, Irene Ramos, Venugopalan D. Nair, Alessandra Soares-Schanoski, ...

This enhanced innate immunity likely enables bats to control viral replication early, contributing to their resistance to severe disease from highly pathogenic viruses.