and the suppressive role of SMYD3 in antiviral innate immunity depended on its enzymatic activity. The knockout of SMYD3 or the inhibition of its enzymatic activity enhanced antiviral gene ...

Expert Rev Clin Immunol. 2008;4(4):497-514. Cytotoxic T cells directed against the viral HA have been found to contribute to lung injury, principally through the release of TNF-α. [139] The ...

fungal or viral infection, genotoxic stress or tissue damage. The ‘pre-programmed responses elicited by these receptors enable the innate immune system to perform with its hallmark rapidity ...

“Before we started this project . . . we knew our genomes were full of these elements and many of them are activated during normal development in cells,” said study coauthor Edward Chuong, a postdoc ...

Our cells harbor a DNA detector termed cGAS to inform the immune system of viral and bacterial infections, cell death, as ...

Researchers at The Wistar Institute's HIV Cure and Viral Diseases Center have successfully ... the key function of the body's innate immune system. Sometimes this process fails, causing the ...

A research led by Sergio P. Acebrón, Researcher Ikerbasque at the UPV/EHU, develops a key tool to visualize the immune response to abnormal DNA, opening new avenues for the treatment of diseases.

On the other hand, mRNA of selenoprotein P binds to the regulatory domain (RD) of RIG-I, inhibiting production of type I interferon (IFN-β) that has antiviral activity. As a result, viral ...

These therapies employ a different branch of the immune system called innate immunity that can help overcome cancer’s ability to evade immune recognition early in an immune response. By ...