Virus-associated cancers are a significant and persistent global health challenge, providing unique insight into the relationship between chronic infection ...

Innate immune sensors—known as pattern recognition receptors (PRRs)—detect specific molecular components of bacterial or ...

SARS-CoV-2 has an enzyme that can counteract a cell's innate defense mechanism against viruses, explaining why it is more infectious than the previous SARS and MERS-causing viruses. The discovery may ...

A team led by researchers at the University of Cologne has identified a protein called ANKIB1 that acts as a volume dial for the body’s frontline immune defenses, controlling how strongly cells ...

The innate immune response constitutes the body’s first line of defence against pathogens, utilising a network of pattern recognition receptors (PRRs) and signalling molecules to detect and neutralise ...

Researchers show how LGP2 binds viral RNA ends, moves along the strand, and helps MDA5 form filaments that amplify antiviral signaling. The findings clarify an early defense step and may inform ...

Mammalian immunity has long been thought to rely solely on proteins and specialized immune cells. However, a newly proposed concept—RNA immunity—is reshaping this perspective. In a recent publication ...

New findings on how past viral respiratory infections affect future, unrelated ones could lead to therapies for boosting general antiviral immunity -- and potentially pandemic preparedness. More than ...

Viruses are masters of stealth. From the moment a virus enters the host's body, it begins hijacking its cells. First, the virus binds to a specific protein on the cell's surface through a lock-and-key ...

TLR4 recognizes bacterial-derived lipopolysaccharides and activates IRF3 via the adapter protein TRIF, contributing to the induction of type I IFN genes. Within endosomes, TLR3, TLR7, and TLR9 ...

When a cell is invaded by a virus, the cell triggers an innate immune response by activating retinoic acid-inducible gene I (RIG-I) like receptors (RLRs), among others, that are essential for ...