Our cells rely on tightly regulated signaling pathways to control when they grow, divide and survive. When these regulatory ...

A new study led by Marco Fumasoni, principal investigator at Fundação GIMM, shows that evolution can substantially reduce ...

Scientists at Nagoya University in Japan studied what happens when macrophages—a type of immune cell—encounter dying cancer cells in tumors and discovered a mechanism that accelerates tumor growth.

mTORC1 promotes cell growth by sensing nutrients and driving anabolic processes. When nutrients are scarce, GATOR1 turns off growth signals. Our study describes how KICSTOR links GATOR1 to lysosomes ...

Fighting cancer effectively often involves stopping cancer cells from multiplying, which requires understanding proteins that the cells rely on to survive. Protein profiling plays a critical role in ...

In this Review, we first briefly discuss ligand specificity of IR and IGF receptor. We then focus on recent structural and functional insights into the activation of IR family receptors and highlight ...

Researchers say approach could be useful for both initial treatment of bladder cancer as well as treatment refractory subsets of tumors.

From enhancing wound healing to combating neurodegeneration and cancer, growth hormone-releasing hormone and its analogs reveal groundbreaking roles that could redefine future therapies. Study: Growth ...

Researchers at Hospital for Special Surgery (HSS) have identified a specialized population of immune cells that play a ...

The growth plates contain special stem cells that continuously produce new cartilage cells, which are converted into bone tissue. In the case of growth disorders in children with a height ...