Sprague–Dawley rats 4–5 weeks old and 120–130 g in body weight were used. To produce liver cirrhosis, 1% DMN dissolved in saline was given intraperitoneally at 1 ml per kg body weight for 3 ...

Metabolic dysfunction-associated fatty liver disease (MAFLD) has become a growing global health concern, affecting millions ...

Metabolic dysfunction-associated steatohepatitis (MASH) significantly increases the risk of liver cirrhosis and hepatocellular ... researchers found that hepatocyte-specific knockout of βKlotho ...

When the liver is persistently inflamed, its cells (hepatocytes) begin to die and ... Over time, extensive fibrosis leads to cirrhosis, where the liver becomes permanently scarred and hardened.

Solute carrier (SLC) family transporters are crucial transmembrane proteins responsible for transporting various molecules, including amino acids, electrolytes, fatty acids, and nucleotides. To date, ...

Investigators have found that the gene Asah1 plays a crucial protective role in preventing the progression of nonalcoholic ...

Ready to save your liver? Transcription factors are paving the way for metabolic dysfunction-associated fatty liver disease ...

as inhibitors of the transformation of stellate hepatocytes into myofibroblasts, the process responsible for the deposition of collagen fibres leading to cirrhosis. The key mechanism that ensures ...

Hepatic steatosis, often triggered by non-alcoholic fatty liver disease (NAFLD), is a leading cause of liver dysfunction globally, affecting approximately 30% of the population.

The phase of immune detection/clearance starts when the host immune system tries to clear HBV-infected hepatocytes ... an increased risk of progression to cirrhosis and HCC.

Hepatic stellate cells reside between the hepatocytes and small blood vessels ... leading to chronic fibrosis or cirrhosis. Liver fibrosis develops from excessive matrix produced by activated ...