Sprague–Dawley rats 4–5 weeks old and 120–130 g in body weight were used. To produce liver cirrhosis, 1% DMN dissolved in saline was given intraperitoneally at 1 ml per kg body weight for 3 ...

When the liver is persistently inflamed, its cells (hepatocytes) begin to die and ... Over time, extensive fibrosis leads to cirrhosis, where the liver becomes permanently scarred and hardened.

Metabolic dysfunction-associated steatohepatitis (MASH) significantly increases the risk of liver cirrhosis and hepatocellular ... researchers found that hepatocyte-specific knockout of βKlotho ...

Solute carrier (SLC) family transporters are crucial transmembrane proteins responsible for transporting various molecules, including amino acids, electrolytes, fatty acids, and nucleotides. To date, ...

Ready to save your liver? Transcription factors are paving the way for metabolic dysfunction-associated fatty liver disease ...

as inhibitors of the transformation of stellate hepatocytes into myofibroblasts, the process responsible for the deposition of collagen fibres leading to cirrhosis. The key mechanism that ensures ...

Hepatic steatosis, often triggered by non-alcoholic fatty liver disease (NAFLD), is a leading cause of liver dysfunction globally, affecting approximately 30% of the population.

Investigators have found that the gene Asah1 plays a crucial protective role in preventing the progression of nonalcoholic ...