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A missing link in the MHC class divergence puzzle: Class II came first

Which came first, MHC class I or MHC class II? For decades, it has been debated which of these two similar classes came first in evolution. Now, Keiichiro Hashimoto and his group at Fujita Health ...
JSTOR Daily

Significance of Lyt Phenotypes: Lyt2 Antibodies Block Activities of T Cells That Recognize Class 1 Major Histocompatibility Complex Antigens Regardless of Their Function

The effect of anti-Lyt2 on the generation of helper T-cell function and on cytotoxic effects specific for subregions of the major histocompatibility complex (MHC) was determined. The addition of ...
Nature

Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps–SHP-2 pathway

The molecular mechanisms that fine-tune Toll-like receptor (TLR)-triggered innate inflammatory responses remain to be fully elucidated. Major histocompatibility complex (MHC) molecules can mediate ...
News Medical

Study reports SARS-CoV-2 accessory proteins downregulate MHC-I expression using distinct mechanisms

In a recent study posted to the bioRxiv* preprint server, researchers observed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) downregulates the expression of major histocompatibility ...
Nature

MHC class I typing in a songbird with numerous loci and high polymorphism using motif-specific PCR and DGGE

The major histocompatibility complex (MHC) has a central role in the specific immune defence of vertebrates. Exon 3 of MHC class I genes encodes the domain that binds and presents peptides from ...
JSTOR Daily

Ectopic Expression of Retinoic Acid Early Inducible-1 Gene (RAE-1) Permits Natural Killer Cell-Mediated Rejection of a MHC Class I-Bearing Tumor in vivo

Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 20 (Sep. 25, 2001), pp. 11521-11526 (6 pages) In 1986, Kärre and colleagues reported that natural killer ...