Figure 1: Structure of the HOIP RBR/UbcH5B~ubiquitin transfer complex. Figure 2: The HOIP RING1–IBR coordinates the UbcH5B~ubiquitin conjugate in a bipartite manner tailored to a HECT-like mechanism.

Researchers have learned how a synthetic molecule destroys complexes that induce allergic responses -- a discovery that could lead to the development of highly potent, rapidly acting interventions for ...