As your disease gets worse, your spleen can become enlarged ... You may also have an enlarged liver or high blood pressure in the veins that enter it. This means it can’t work like it should.

enlarged spleen, red palms, yellowing of the skin and eyes, or jaundice. MASH that turns into cirrhosis could cause these symptoms: Many people with SLD or fatty liver disease have a normal life ...

Children and adults with Niemann-Pick type C can have an enlarged liver, an enlarged spleen, and lung disease. The diagnosis of Niemann-Pick type C depends on the clinical history and physical ...