Nature

Inhibition of integrin linked kinase (ILK) suppresses β-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC−/− human colon ...

Loss of functional adenomatous polyposis coli (APC) protein results in the stabilization of cytosolic β-catenin and activation of genes that are responsive to Lef/Tcf family transcription factors. We ...
Le télégramme

UBO. Préparation au TCF-ANF

Le Service universitaire de formation continue de l'UBO organise une session de tests de connaissance en français (TCF). Le TCF pour l'accès à la nationalité française (ANF) est conçu pour répondre ...
Nature

PKG inhibits TCF signaling in colon cancer cells by blocking β-catenin expression and activating FOXO4

Activation of cGMP-dependent protein kinase (PKG) has anti-tumor effects in colon cancer cells but the mechanisms are not fully understood. This study has examined the regulation of β-catenin/TCF ...