Immune checkpoint blockade (ICB) therapies can be very effective against some cancers by helping the immune system recognize cancer cells that are masquerading as healthy cells. T cells are built ...

Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center for Cancer Biology and ...

Researchers developed an innovative nano-immune agonist that significantly improves immunotherapy outcomes for melanoma - a ...

Cancer is a prevalent ... Hidetoshi Hayashi et al, Soluble immune checkpoint factors reflect exhaustion of antitumor immunity and response to PD-1 blockade, Journal of Clinical Investigation ...

The dual checkpoint blockades also demonstrated that CTLA-4 checkpoint blockade maintained a pool ... head and neck squamous cell cancer, and kidney cancer. “We wanted to develop an immune-monitoring ...

Feasibility and safety results from RAD-IO: A multi-stage trial of durvalumab (Medi4736) with chemoradiotherapy with 5-fluorouracil and mitomycin C in patients with muscle-invasive bladder cancer.