PD-1 blockade conferred benefit to certain women with surgically resectable endometrial cancer, findings presented at Society ...

Immune checkpoint blockade (ICB) therapies can be very effective against some cancers by helping the immune system recognize cancer cells that are masquerading as healthy cells. T cells are built ...

known as immune checkpoints. In this article, explore how the research into blocking these checkpoints has led to immune checkpoint inhibitors (ICIs), a promising but still evolving class of ...

Hayashi. The team assessed the soluble forms of immune checkpoint molecules, PD-L1, PD-1, and CTLA-4 in the blood samples of patients with advanced NSCLC before PD-1/PD-L1 blockade therapy.

Feasibility and safety results from RAD-IO: A multi-stage trial of durvalumab (Medi4736) with chemoradiotherapy with 5-fluorouracil and mitomycin C in patients with muscle-invasive bladder cancer.

in addition to the blockade of the immune checkpoint. At this time, there are no other indications being pursued formally by CKPT for cosibelimab as a single agent, although there is a planned ...

Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related deaths worldwide.

2 These proteins turn off the immune system and prevent it from killing cancer ... The dual checkpoint blockades also demonstrated that CTLA-4 checkpoint blockade maintained a pool of progenitor T ...