Ageing is a complex and multifaceted process, resulting in functional decline and heightened vulnerability to diseases across various organ systems and tissues. Notably, the immune and skeletal ...

Panelists discuss how immunoglobulin A (IgA) nephropathy develops through a complex 4-hit cascade involving aberrant IgA1 glycosylation, anti-glycan antibody formation, immune complex deposition, and ...

It has only recently become known that two parallel systems of blood formation exist in the body, originating from different precursor cells. Researchers at the German Cancer Research Center (DKFZ) ...

Immunoglobulin A (IgA) nephropathy is an autoimmune disease characterized by the deposition of circulating IgA-containing immune complexes (IgA-ICs) in the glomerular mesangium, leading to mesangial ...

Membranous nephropathy (MN) is a primary glomerular disease commonly causing adult nephrotic syndrome, about 80% of MN cases don’t have clear secondary cause, called idiopathic membranous nephropathy ...

Immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) is a rare disease that affects the filtering units in your kidneys (glomeruli). There are many types of glomerular diseases.

Kidney Disease: Improving Global Outcomes (KDIGO) has issued comprehensive, evidence-based recommendations for clinicians managing immunoglobulin A nephropathy (IgAN) and immunoglobulin A vasculitis ...

C3 glomerulopathy (C3G) and immune complex membranoproliferative glomerulonephritis (IC-MPGN) are rare kidney conditions caused by an overactive complement system, part of the immune system. C3G ...

Rheumatoid arthritis is associated with an atypical immune response called a type 3 hypersensitivity reaction. This reaction happens due to immune complexes in the body. It can be treated by ...

Many vaccines work by introducing a protein to the body that resembles part of a virus. Ideally, the immune system will produce long-lasting antibodies recognizing that specific virus, thereby ...

Gastrointestinal (GI) malignancies—including esophageal, gastric, colorectal, hepatic, and pancreatic cancers—constitute a major global health burden and ...