8,9 Although each patient experiences SLE differently, they all have one thing in common: their immune system is attacking ... important manifestations is lupus nephritis (LN): inflammation ...

An important characteristic of immune system activation in SLE is ... Glomerular upregulation of CCL2/MCP-1 and CCL5/RANTES mediates the infiltration of leukocytes into the glomerulus in murine ...

In lupus, something goes wrong with the immune system. “Instead of the immune system fighting ... people with lupus will develop lupus-related kidney disease, known as lupus nephritis. Visit our Lupus ...

The FDA has agreed to review an application from Roche that seeks approval in the U.S. of obinutuzumab as a treatment for ...

1 More than 1.5 million people develop one of the most dangerous manifestations of SLE: lupus nephritis (LN), characterized by immune system induced inflammation of the kidneys. Within 10 years ...

Autoimmune diseases make the immune system attack healthy tissues. These can affect organs like kidneys, leading to conditions such as Lupus Nephritis and Rheumatoid Arthritis. Diagnosis can be ...

We recently discovered that patients with the worst type of lupus nephritis (class 3 and 4) have high levels of IL-16 in the kidneys. IL-16 is a compound that immune cells make to attract and activate ...

Research shows multiple factors drive CKD risk in lupus nephritis, including nephritic flares, baseline hypertension, renal ...

It is currently being tested against acute graft-vs-host disease (aGVHD), lupus nephritis ... targeting single cytokines to shut down runaway immune responses. In 2013, itolizumab received ...

Genentech, a Roche Group company(OTCQX:RHHBY) said on Wednesday that the U.S. FDA accepted the company’s supplemental Biologics License Application ((sBLA)) for Gazyva to treat lupus nephritis. Lupus ...

GlobalData predicts that Gazyva could generate up to $1.7bn in sales by 2030 if approved for lupus nephritis. Genentech is also studying Gazyva in other autoimmune indications, including SLE ...

Systemic lupus erythematosus is a complex autoimmune disorder affecting multiple ... Conventional lupus nephritis (LN) treatment based on cyclophosphamide, steroids and, recently ...