(A) Schematic diagram of the experimental system that detects calcium release from the endoplasmic reticulum by each ryanodine receptor. (B) Isoflurane selectively activates RyR1 (mean ± standard ...

Since their anesthetic effects were discovered approximately 180 years ago, inhalational anesthetics have been used for general anesthesia in surgical operations. However, the mechanism of their ...

The first successful public demonstration of the inhalational induction of anesthesia took place in the surgical amphitheater of Massachusetts General Hospital on October 16, 1846. The news spread ...

A tiny calcium channel called RyR1 may be the switch that turns on anesthesia during surgery. #medindia #anesthesia #calciumchannels’ In rare cases, patients with abnormal type 1 ryanodine receptors ...

An article, published in Scientific American, explained the inner workings of anesthesia and the mystery that surrounds general anesthetics’ molecular mechanisms. Rochester, Minn.-based Mayo Clinic’s ...

The application of general anesthesia in clinical therapy has been an indispensable part of modern medicine for more than a century. However, due to the complexity of the brain and the extensive ...

The case of a Missouri patient who was awake during surgery is making headlines, as it appears that his sevoflurane was never turned on, leaving him aware for at least 13 minutes of his procedure.

There’s a lot more to “going under” than just counting down from ten and then waking up when the surgery is over, although it’s great we can do that. Here’s how anesthesia affects you, what makes it ...

Cannabis users aged 65 years or older undergoing general anesthesia for surgery required higher doses of inhalational anesthetics than nonusers. However, the clinical relevance of this difference ...

Acute neuronal injury has devastating consequences with increased risks of morbidity and mortality. Among its survivors, neurological deficit is associated with loss of function, independence and ...

Since their anesthetic effects were discovered approximately 180 years ago, inhalational anesthetics have been used for general anesthesia in surgical operations. However, the mechanism of their ...