In the healthy liver, most macrophages are classified as Kupffer cells (KCs). However, upon liver injury, as seen, for example, in obesity, another subset of macrophages called lipid-associated ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to date. Researchers have now determined that ...

The earliest changes in stellate cells are likely to result from paracrine stimulation by all neighboring cell types, including sinusoidal endothelium, Kupffer ... cell type in liver, are a ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type ...

Activation of monocytes (Kupffer cells) was determined with a pulse of carbon (arrows, black grains). A: Healthy liver with limited carbon incorporation indicates most Kupffer cells are inactive.

New research suggests restoring stellate cells to their healthy and protective state could simultaneously reduce liver scarring and improve liver function.

In 1876, Karl Wilhelm von Kupffer identified what he believed to be a single type of star-shaped cell in liver tissue. Now, immunologist Martin Guilliams from Ghent University and the VIB ...

Regularly consuming warm lemon water, artichoke tea, apple juice, or mung bean water can help detoxify and support liver ...

The liver is largely comprised of hepatocytes, but Kupffer cells, endothelial cells and hepatic stellate cells are also present. Applications of hPSC-derived organoids have been hampered by ...

The liver is difficult to palpate in women during ... There may be a slight increase in Kupffer cells, which contain increased amounts of periodic acid-Schiff (PAS)-positive granules.

and Kupffer cells act as a protective barrier. Hepatic stellate cells are located along the specialized blood capillaries of the liver, known as sinusoids. They are known to drive liver fibrosis ...