CD8⁺ T cells respond to short peptides bound to MHC class I molecules. Although most antigenic proteins contain many sequences that could bind to MHC class I, few of these peptides actually stimulate ...
MHC class II molecules are central to the adaptive immune response, serving as the means by which antigen-presenting cells, notably dendritic cells, display processed peptides to CD4+ T cells. This ...
Which came first, MHC class I or MHC class II? For decades, it has been debated which of these two similar classes came first in evolution. Now, Keiichiro Hashimoto and his group at Fujita Health ...
The impact of skeletal muscle and adipose tissue on long-term survival in patients with resectable colorectal cancer. This is an ASCO Meeting Abstract from the 2018 ASCO Annual Meeting I. This ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 20 (Sep. 25, 2001), pp. 11521-11526 (6 pages) In 1986, Kärre and colleagues reported that natural killer ...
Our core provides customized MHC/peptide tetramers for identification of antigen-specific T lymphocytes by flow cytometry. Tetramers and/or their derivatives are provided for research purposes only.
HLA (Human Leukocyte Antigen) typing is important in organ transplantation protocols, as they determine the likelihood of rejection. The HLA system is little understood, however. In simple terms, the ...
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