YF550-C1, an E3 ligase inhibitor of CBL-B, to demonstrate T cell and NK cell activation and anti-tumor activities in syngeneic and PDX tumor model. This is an ASCO Meeting Abstract from the 2024 ASCO ...

CD47 expression levels may predict evorpacept efficacy in HER2-positive metastatic breast cancer, especially in heavily pretreated patients. Evorpacept combined with zanidatamab shows promising ...

Macrophages rely on lysosomes to balance microbial killing with self-protection, generating reactive oxygen and nitrogen species during phagocytosis. Using platinum nanoelectrodes, researchers at ...

Platinum nanoelectrodes measure reactive oxygen and nitrogen species emitted at a macrophage phagocytic cup, revealing how lysosomal pH modulates ROS/RNS flux during frustrated phagocytosis of a glass ...

Study findings map out a new way in which antiviral signals engage with cellular metabolism to balance defense and repair.

Scientists at Nagoya University in Japan studied what happens when macrophages—a type of immune cell—encounter dying cancer cells in tumors and discovered a mechanism that accelerates tumor growth.

Macrophages are white blood cells that play a key role in helping to protect us against microscopic threats, from infections to cancer. These cells constantly survey the body’s tissues and consume ...

PALO ALTO, Calif.--(BUSINESS WIRE)--Pheast Therapeutics (“Pheast”), a biotech developing novel macrophage checkpoint therapies to defy cancer, today announced the presentation of new preclinical data ...

Indian researchers reveal how immune cells 'betray' the body, aiding breast cancer spread and suggesting new treatment ...