Histologically, NASH is defined by hepatic steatosis, lobular inflammation and hepatocellular ballooning ... also seem to have positive effects on liver function and histology.

Adipose tissue macrophages may also inhibit adipocyte differentiation, leading to altered adipokine secretion and ectopic storage of fat in non-adipose tissues, including liver and skeletal muscle.

Studies investigating the results of treatments through conventional light microscopy histology in human nonalcoholic fatty liver disease ... necroinflammation and ballooning at light microscopy.