A) The structure of TLRs is characteristic of ... The ligand binds to a site in the extracellular domain of the receptor (not shown) and induces a conformational change that activates the ...
Northwestern University researchers have identified structural features in engineered cell receptors that correlate with ...
In this study, the authors first used an AlphaScreen assay to identify a series of tryptophan-based cyclic peptide compounds with FXR-antagonistic activity, specifically those modified with a ...