Multidrug resistance associated with the overexpression of the multidrug transporter P-glycoprotein is a serious impediment to successful cancer treatment. We found that verapamil reversed resistance ...

Researchers have mapped the conformational changes that occur in a protein 'notorious' for pumping chemotherapeutic drugs out of cancer cells and blocking medications from reaching the central nervous ...

Many peptides and transmitters found within the brain also have peripheral sites of action. We now demonstrate that the brain releases functionally active ...

The human P-glycoprotein transporter gene (ABCB1), also known as the multidrug resistance 1 gene (MDR1), acts to expel many immunosuppressive drugs to the outside of the cell. Such drugs are often ...

WHEN CANCERS STOP responding to chemotherapy, one of the culprits is a protein transporter that expels drugs out of diseased cells, thereby preventing the benefits of treatment. Now researchers are ...

More recently, members of the multidrug resistance P-glycoprotein (MDR/PGP) subfamily of ABC transporters have been shown to function in the transport of the phytohormone auxin in both monocots and ...

Deep space is most likely going to be humanity’s final frontier, and space travel will undoubtedly become much more common in the future. However, space is a very hostile environment not only because ...

CHAMPAIGN, Ill. — Researchers have tried for decades to understand the undulations and gyrations that allow transport proteins to shuttle molecules from one side of a cell membrane to the other. Now ...

\A team of SMU biological scientists has confirmed that P-glycoprotein (P-gp) has the ability to remove a toxin from the brain that is associated with Alzheimer's disease. The finding could lead to ...

Keeping brain amyloid-β (Aβ) levels in check means controlling both the means of production and the method of disposal. On the disposal side, a few years ago researchers recognized for the first time ...

Researchers have tried for decades to understand the undulations and gyrations that allow transport proteins to shuttle molecules from one side of a cell membrane to the other. Now scientists report ...

DALLAS (SMU) -- A team of SMU biological scientists has confirmed that P-glycoprotein (P-gp) has the ability to remove a toxin from the brain that is associated with Alzheimer's disease. The finding ...