Panelists discuss how immunoglobulin A (IgA) nephropathy develops through a complex 4-hit cascade involving aberrant IgA1 glycosylation, anti-glycan antibody formation, immune complex deposition, and ...

Crohn's disease and ulcerative colitis are idiopathic, chronic, relapsing, inflammatory conditions that are immunologically mediated. Although their exact etiologies remain uncertain, results from ...

The pathogenesis of polycystic ovary syndrome (PCOS) is not precisely known. There are several mechanisms that have been suggested to play a role in the pathogenesis of PCOS, including hormonal ...

Fatty liver diseases (FLD) have become a significant health concern worldwide, affecting millions. The two most common types of FLD are non-alcoholic fatty liver disease (NAFLD) and ...

Like all forms of cancer, lung cancer is defined by uncontrolled cell division caused by loss of physiological tissue homeostasis and failure of apoptotic cell death mechanisms. Aberrant cell ...

The etiopathogenesis of ankylosing spondylitis (AS) is not fully understood. However, there is strong evidence indicating that genetic factors play a pivotal role in disease susceptibility, and that ...

Identification and Validation of Novel Therapeutic Targets for Multiple Myeloma Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous clinicopathologic entity accounting for 30% of non-Hodgkin's ...

Emerging and re-emerging viral threats continue to pose critical challenges to global health security. Despite substantial advances in our understanding of ...

Familial Hypobetalipoproteinemia (FHBL), caused by variants in the apolipoprotein B (APOB) gene, is a rare autosomal ...