Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...

In their 23 cases of NASH cirrhosis, 20 were definite and 3 were probable; ballooning, not a required feature, was noted in 91% of cases and residual perisinusoidal fibrosis was found in 78%.