As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

The liver is the body’s chemical factory, where most metabolic processes take place. It processes everything you eat and drink, converting them into energy and essential nutrients. Additionally, the ...

Data from pivotal Phase 3 trial in CHB-associated liver fibrosis expected in Q2 2025Commercial launch in the PRC of generic nintedanib for the ...

Medically reviewed by Jay N. Yepuri, MD Metabolic dysfunction-associated steatohepatitis (MASH) is an advanced form of ...

FibroScan overestimated advanced fibrosis and cirrhosis in patients with class 3 obesity and metabolic dysfunction-associated steatotic liver disease.

The liver is essential for digestion, metabolism, detoxification, and fluid regulation. While alcohol abuse is a known cause ...

Maternal diet, excess bile acid and liver disease - Moms who eat a high-fat, high-sugar diet during pregnancy can increase ...

Mechanistically, icosabutate improved fibrosis independent of reductions in liver fat or body weight ... single reader F2-F3 phase 2 MASH studies. A ≥1-stage improvement in fibrosis was seen ...

New research suggests restoring stellate cells to their healthy and protective state could simultaneously reduce liver scarring and improve liver function.