RNA sequencing (RNA-seq) is a powerful tool in diagnosing Mendelian disorders, but the optimized sequencing depth for this ...

Two new research papers from the Living Brain Project at Mount Sinai present what is, by several metrics, the largest ...

Peking University, June 27, 2025: To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian cells, researchers from Peking University ...

SANTA CRUZ — A Ph.D. graduate student in biomolecular engineering at UC Santa Cruz, with a background in computer science and mathematics, has created an innovative software program called CRISPRware, ...

In modern functional genomics, understanding how specific genes control cellular behavior requires both targeted intervention and high-resolution analysis. That’s where Perturb-Seq comes in—a method ...

However, traditional protocols that rely on Moloney murine leukemia virus (MMLV) reverse transcriptases (RTs) often fall ...

It's no secret that we need new ways to treat and detect disease, including cancer. Specifically, we need better biomarkers that can be used for diagnosis and better ways to selectively get medicine ...

CRISPR-Cas systems are adaptive immune systems found in prokaryotes that defend against invading nucleic acids through CRISPR RNA-guided cleavage. Type V CRISPR-Cas (Cas12) systems, in particular, ...