Prognostic Value of Neurotrophic Tyrosine Receptor Kinase Gene Fusions in Solid Tumors for Overall Survival: A Systematic Review and Meta-Analysis Recent larger-scale studies of patients with cancer ...

Telomere shortening is a well-characterized cellular aging mechanism, and short telomere syndromes cause age-related disease. However, whether long telomere length is advantageous is poorly understood ...

Darwin's theory of evolution was originally developed in the context of speciation. It has proved to be a fundamental property of biologic systems, including human cancers. Although tumor evolution ...

The physical elimination of self-reactive lymphocyte clones (clonal deletion) is a central tenet of the clonal selection theory, and has been a major focus of immunologists since the introduction of ...

Historical Insight: During those periods when immunology was oriented toward medical or biological subjects, Darwinian concepts predominated. These included Metchnikoff's phagocytic theory and Ehrlich ...

Current Clonal Selection Theory fails to adequately explain the presence of a “hyper mutation” particularly in 3 CDR sections of a V part of Ig genes, which are responsible for recognition and binding ...