What are spherical nucleic acids (SNAs)? What do they consist of and how do they differ from linear nucleic acids? Spherical nucleic acids are structures that are made by taking a nanoparticle ...

Nucleic acids are chains of nucleotides that are a vital part of all living beings. The two most common types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), which provide ...

Peptide nucleic acids (PNAs) represent a revolutionary class of synthetic nucleic acid analogues, in which the traditional sugar–phosphate backbone is replaced by a neutral N-(2-aminoethyl) glycine ...

DNA is the poster child for high-specificity binding. As long as their base sequences match, two complementary strands of DNA can navigate through a sea of biomolecules, find each other, and hold fast ...

Some biologists have long hoped that small pieces of RNA that silence genes could help wipe out genetic diseases. But developing nucleic acid medications with good drug properties, such as selectivity ...

Endosomal and cytosolic nucleic acid receptors sense microbial nucleic acids and initiate innate immune responses. However, in some circumstances their activation by endogenous nucleic acids can also ...

Gastrointestinal (GI) cancers remain a major global health burden, accounting for substantial cancer-related morbidity and mortality worldwide. Cell-free ...

The research focus of the Müller group is the bioinorganic chemistry of nucleic acids with a particular emphasis on the generation, characterization as well as application of nucleic acids including ...

Nucleic acids such as DNA and RNA play a central role in gene therapies and vaccines. They store and transmit biological information. In order for them to work in the body, they must enter the cells ...