The human brain develops over decades, making this process notoriously difficult to model in a dish. Now, scientists have taken a step toward this goal. As described in preprint posted October 2 on ...

In a new proteomics extravaganza, scientists have unearthed groups of proteins that appear to be at the heart of Alzheimer’s disease pathogenesis. As described in Cell on September 25, scientists led ...

Synonyms: High-copy SOD1-G93A, B6SJL.SOD1-G93A, Tg(hSOD1-G93A)1GUR mice, Gurney mice ...

SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available.

Biogen’s hopes for a quick regulatory approval of its anti-Aβ antibody aducanumab may be dimming. An advisory panel convened by the U.S. Food and Drug Administration was unimpressed by the evidence ...

Score another one for amyloid immunotherapy. The anti-pyroglutamated amyloid antibody donanemab has posted positive top-line results in the Phase 3 Trailblazer-Alz2 study, according to an Eli Lilly ...

The slight slowing of cognitive decline achieved by Leqembi and perhaps by Aduhelm has revived debate around how much change is needed to be “clinically meaningful.” Two recent papers—one a report ...

Rare variants in TREM2 and PLCG2 influence a person’s odds of developing Alzheimer’s disease, but that is far from all the two genes have in common. According to a study published June 8 in Nature ...

A potential treatment for Alzheimer’s disease relies on 40 Hz light or sound to entrain gamma rhythms in the brain. This intervention, pioneered by Li-Huei Tsai and colleagues at Massachusetts ...

A routine shunt surgery improves clinical care for people with hydrocephalus. Nearly half have Alzheimer's pathology, offering a natural model of LOAD. Every week, neurosurgeons supply ...

Autosomal-dominant mutations underlie about 40 percent of frontotemporal dementia cases. This strong genetic component comes with a silver lining—it gives scientists a clear therapeutic target. At the ...

For decades, the U.S. Food and Drug Administration has taken a light touch to regulating diagnostic tests that use body fluids or tissues. Such assays, very much including cerebrospinal fluid and ...