CRISPR-Cas systems are prokaryotic immune systems that confer resistance to foreign genetic elements such as plasmids and phages. CRISPR-Cas systems have been exploited for targeted genome editing.

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the double ...

This repository provides learning and reference material for developing IRB-compliant retail Probability of Default (PD) models, using a mortgage-style retail portfolio as the primary example. The key ...

Contracts are enforced by deterministic Python code external to the model. The model cannot modify, bypass, or reason about them. This addresses a fundamental problem in agent security: LLMs cannot ...