Previously, the opioid analgesic drug JCT801 was reported to induce cell death via disruption of pH homeostasis in pancreatic cancer cells. Here, the authors investigate the metabolic mechanisms ...

SARS-CoV-2 is a positive-sense single-stranded RNA virus. It is contagious in humans and is the cause of the coronavirus disease 2019 (COVID-19). A SARS-CoV-2 antibody, NT-108, exhibits potent ...

Molecular dynamics is a method that uses Newton’s equations of motion to computationally simulate the time evolution of a set of interacting atoms. Such techniques are dependent on a description ...

This Review provides an update on the role of innate and adaptive immune cells in the pathogenesis of osteoarthritis. The authors discuss emerging therapeutics that target the immune system in ...

Antibodies are secreted immunoglobulin molecules produced mainly by plasma cells. The antigen-binding site of the antibody has a unique structure that allows it to bind antigen in a highly ...

In this Journal Club, Minoli Perera reflects on a 2005 sequencing study by Cohen et al., who discovered two common loss-of-function mutations with large effects on plasma cholesterol levels thanks ...

Inflammation is a biological response to harmful stimuli, such as pathogens, damaged cells or irradiation. It is a protective attempt by the organism to remove injurious stimuli and to initiate ...

The exact role FoxO3 in the regulation of cardiac regeneration remains unclear. Here, the authors show that FoxO3 negatively controls cardiomyocyte proliferation and heart regeneration in ...

Peru has the longest wait for its next win in Miss Universe history, as Gladys Zender first won the title in 1957. The half-Swiss was a 17-year-old sensation and was the first Lat ...

Words and art will converge at The Jung Center’s annual fundraising dinner on Tuesday at the River Oaks Country Club. The evening will culminate with a speech by Clint Smith, who was raised in New ...

Evolution is the process of heritable change in populations of organisms over multiple generations. Evolutionary biology is the study of this process, which can occur through mechanisms including ...

Simon Schlehuber and colleagues model autonomous hydrogen-powered boats as a sustainable transport solution and find potential cost benefits over longer distances. This research could inform ...