[6] Initiation refers to early paracrine-mediated changes in gene expression and phenotype that render the cells responsive to other cytokines ... Kupffer cells, hepatocytes, platelets, and ...

Liver regeneration (LR) is a complex biological process involving the proliferation of parenchymal (hepatocytes ... to produce large amounts of cytokines, which play a crucial role in LR.

Results showed the agent lessened severity of cytokine release syndrome or immune effector cell-associated neurotoxicity syndrome (ICANS) for a majority of treated patients. “We expected to see ...

Figure 1: a, Schedule of DMN administrations and HGF–HVJ liposome or PBS injections. Figure 3: a–c, Liver sections of rats after DMN administration. Sprague–Dawley rats 4–5 weeks old and ...

Hepatocellular DILI is linked to inflammation, apoptosis, and necrosis ... which can lead to hepatocyte and cholangiocyte damage. UDCA mitigates these effects by replacing toxic bile acids ...

and from injured hepatocytes (green). Oxidative stress, cytokine release, endotoxin, and ethanol and its metabolites can stimulate paracrine chemokine secretion from all of these sources.

Hepatocellular DILI is characterized by inflammation, necrosis, and apoptosis, while cholestatic ... and immune-mediated ...

MicroRNAs (miRNAs) are key contributors to liver diseases progression. This study investigated hepatocyte-abundant miRNAs dysregulated by ALD, its impact on hepatocyte injury and the underlying basis.

In this review, we cover recent discoveries in new targets and molecules for antifibrotic treatment, which target pathways intertwined with the fibrogenesis process, including lipid metabolism, ...

For example, the production of ROS and metabolites from the TCA cycle, including citrate, itaconate, and succinate, regulate the secretion of inflammatory cytokines, antimicrobial responses, and ...

Both authors share equal and corresponding authorship. The helminth diseases schistosomiasis, opisthorchiasis, and clonorchiasis are highly carcinogenic. Trypanosoma cruzi has a dual role in cancer ...