Cuproptosis, a form of cell death, may link copper imbalance and atherosclerosis
Atherosclerosis (AS) is a chronic inflammatory disease characterized by the buildup of lipids and immune cells in arterial ...
EMBO Press1d
PARP7 as a new target for activating anti-tumor immunity in cancer
PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...
Healio14d
Siltuximab reduces severity of cytokine release syndrome, ICANS after CAR T-cell therapy
Results showed the agent lessened severity of cytokine release syndrome or immune effector cell-associated neurotoxicity syndrome (ICANS) for a majority of treated patients. “We expected to see ...
EurekAlert!26d
Ursodeoxycholic acid for the management of drug-induced liver injury: Role of hepatoprotective and anti-cholestatic mechanisms
Hepatocellular DILI is linked to inflammation, apoptosis, and necrosis ... which can lead to hepatocyte and cholangiocyte damage. UDCA mitigates these effects by replacing toxic bile acids ...
Medscape1mon
The Role of Cytokines and Chemokines in the Development of Steatohepatitis
and from injured hepatocytes (green). Oxidative stress, cytokine release, endotoxin, and ethanol and its metabolites can stimulate paracrine chemokine secretion from all of these sources.
Frontiers3y
The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases
During ischemia, the complex interaction between ER stress, oxidative stress, and inflammation leads to a large amount of hepatocyte loss during reperfusion, as well as a large number of cell death ...
eLife3y
Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression
However, following tissue-scale chemical induction of hepatocyte apoptosis, ROCK1nc mice had significantly more liver damage and greater levels of neutrophil infiltration. Inhibition of the ...
eLife5y
Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress
ER stress initiates apoptosis through intracellular activation of death receptor 5 (DR5) independent of its canonical extracellular ligand Apo2L/TRAIL; however, the mechanism underlying DR5 activation ...
Frontiers6y
Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-κB Pathway
Results: PPI reduced the inflammatory cytokines production of PEMs stimulated by LPS/IFN ... PEMs or BMMs were used for cell apoptosis analysis, while 0.8 × 10 6 cells were seeded into 12-well plate ...
Medscape13y
From Pathogenesis to Treatment
Thus, for example, NB cells express receptors for IFN-γ and upon interaction with this cytokine undergo growth inhibition, apoptosis or differentiation. All these changes translate into decreased ...