A team led by researchers at Baylor College of Medicine and Washington University School of Medicine has shed light on the ...

Research led by the Department of General and Visceral Surgery, Faculty of Medicine, University of Freiburg, Germany has ...

Mechanistically, the proliferation defect resulted from inhibition of an Fgf15-Fgfr4-Stat3 signalling pathway, which is required for injury-induced expression of the Foxm1 transcription factor and ...

Now scientists have shown that bacteria in the gut microbiome can alter bile acids that are made from cholesterol; the microbes can transform these bile acids into metabolites that help the immune ...

Primary bile acids are produced by the liver and released into the gut, where diverse groups of bacteria work together to modify their chemical structures. Researchers suspected these gut microbial ...

The FGF15/FGFR4/ERK signaling pathway was notably activated in the skeletal muscle tissues of nobiletin-supplemented mice, suggesting a protective effect against muscle atrophy despite the pathway’s ...

They found that in UC patients, the lower levels of 7α-dehydroxylated bile acids strongly correlated with impaired intestinal cell renewal. “… our results obtained from publicly available ...

In a paper in Nature, researchers at the Chinese Academy of Sciences and Xiamen University report that they have identified one such caloric restriction mimetic—a bile acid called lithocholic ...

Microbes living in our guts help us digest food by reshaping the bile acids that our livers produce for breaking down fats. It turns out that two of these microbially-modified bile acids may affect ...

Figure 1. The synthesis and metabolic cycle of bile acids (BAs) involve the liver, intestine, and gut microbiota. BAs are synthesized in hepatocytes via the classic pathway and the alternative pathway ...

FXR agonists, including obeticholic acid (OCA), have demonstrated significant histological improvements, although concerns about pruritus and adverse cardiovascular effects have tempered enthusiasm.

Since FGF21 does not directly activate FGFR4 in vitro or in vivo, and FGFR4 KO has not reached the maximal Cyp7a1 expression levels (a FGFR4 and SHP double KO showed a higher Cyp7a1 level than either ...