gut.bmj17d
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD
Paraformaldehyde-fixed, paraffin-embedded liver tissue was sliced into 5 μm sections and H&E stained. Visualisation was performed using a Leica DFC300 camera. Total RNA was extracted with TRIzol ...
Frontiers3y
Mass Cytometry Study on Hepatic Fibrosis and Its Drug-Induced Recovery Using Mouse Peripheral Blood Mononuclear Cells
The disease occurs in response to chronic liver injury and is mostly driven by the development of inflammation. The primary causes of hepatic fibrosis include alcohol abuse, non-alcoholic ...
eLife3y
The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling
It is generally accepted that IL6-mediated STAT3 signaling in hepatocytes, mediated via glycoprotein 130 (gp130; IL6ST), is beneficial and that the synthetic IL6:IL6ST fusion protein (HyperIL6) ...
Frontiers3y
Nobiletin Alleviates Non-alcoholic Steatohepatitis in MCD-Induced Mice by Regulating Macrophage Polarization
Non-alcoholic steatohepatitis (NASH) is an inflammatory ... Shanghai, China). Liver tissues were fixed with 10% formalin, embedded in paraffin, sectioned, and stained with hematoxylin and eosin (H&E) ...