Scientists highlight problems with ongoing STING inhibitor development strategies and offer an alternative explanation for ...

By studying the innate immune system, scientists have found connections between the immune systems of bacteria and those of humans. “We only started sequencing large numbers of genomes about 20 years ...

The approach employed by the research team could be used against other diseases—including COVID-19 and influenza.

How SARS-CoV-2 defeats the innate immune response. Story by Science X staff • 2w. T he novel coronavirus SARS-CoV-2 has an enzyme that can counteract a cell's innate defense mechanism against ...

Trained immunity in alveolar macrophages can lead to damaging lung inflammation, confirming the importance of context in this phenomenon.

A research team at the University of Münster has investigated for the first time how the confrontation of bacteria with hosts ...

These receptors are part of the innate immune system and serve to instigate an appropriate host response to identify, interrogate, segregate, secure and eliminate the threatening stimulus.

Immunologists have long accepted the “innate-first, adaptive-second” model of the immune response, but following an odd discovery 15 years ago, the line separating the innate and adaptive axes began ...

The strategy of the innate immune response may not be to recognize every possible antigen, but rather to focus on a few, highly conserved structures present in large groups of microorganisms. 1 ...

Insects possess a remarkable ability to develop innate immune memory, and the mechanisms underlying this process are becoming a central topic in innate immunity research.

As a negative regulator of innate immune responses and acute T cell-mediated transplant rejection in mice, Siglec-E offers a potential therapeutic target that may be translatable to humans.

Researchers have long focused on the STING (Stimulator of Interferon Genes) pathway as a way to harness the immune system's natural defenses against ...