The earliest changes in stellate cells are likely to result from paracrine stimulation by all neighboring cell types, including sinusoidal endothelium, Kupffer ... cell type in liver, are a ...

Research from VIB-UGent identifies lipid-associated macrophages and LAM-like Kupffer cells as critical for liver repair. The study reveals TREM2's role in clearing damaged cells and promoting recovery ...

In the healthy liver, most macrophages are classified as Kupffer cells (KCs). However, upon liver injury, as seen, for example, in obesity, another subset of macrophages called lipid-associated ...

Systems and solutions that accelerate drug discovery and development workflows, today announced the launch of its PhysioMimix® DILI assay kit: Human 24.

Our livers contain many different types of immune cells. New research by the team of Prof. Charlotte Scott (VIB-UGent Center for Inflammation Research) and colleagues now reveals that a specific ...

The microvasculature of the liver, known as the sinusoid, interfaces the blood supply with the hepatocytes and is also the location of the hepatic stellate cells and Kupffer cells. Figure 2.

Taken together, we developed a series of nanobodies targeting multiple distinct recognition epitopes of the Kupffer cell ... (28). The liver KCs play an important role in surveillance, uptake of ...

Liver injury in Trem-2-/-mice is associated with elevated levels of reactive oxygen species and lipid peroxidation. In line with TREM-2 effects on inflammation and injury, Kupffer cells and hepatic ...

MerTK-deficient mice exhibit persistent liver injury and inflammation after APAP overdose and are characterised by a depletion in MHCII high-bearing prorestorative resident Kupffer cells and by ...