Once protein synthesis is excessive or misfolded protein becomes aggregated, which eventually overwhelms the capacity of the endoplasmic reticulum (ER), a state named ER stress would be reached. ER ...

A groundbreaking study reveals that neurons can burn fat, challenging the long-held belief that the brain relies solely on glucose for fuel.

Discover how the new technique of HSMP can help scientists gain insights into the world of biological processes and their ...

While glucose, or sugar, is a well-known fuel for the brain, Weill Cornell Medicine researchers have demonstrated that electrical activity in synapses—the junctions between neurons where communication ...

PRD Therapeutics, Inc., a clinical stage company focused on the development of novel lipid metabolism regulators targeting ...

Liver diseases are on the rise globally. Two million people die every year due to liver diseases, and this is about 4% of all ...

In addition, swimming, especially in low temperatures (which results in more energy expenditure), has been shown to stimulate lipid-lipoprotein metabolism in fatty liver. [66] ...

Despite appearances, lean individuals can develop non-alcoholic fatty liver disease (NAFLD), now known as metabolic ...

IBI3030 significantly reduces LDL-c (p<0.01 vs. baseline) and Lp(a), improves oral glucose tolerance (OGTT) (effective even in GLP-1R knockout mice), reduces body weight, and preserves insulin ...

Imagine a condition affecting nearly one-third of the global population, often silently progressing, and deeply intertwined with prevalent health issues like obesity and type 2 diabetes. This is ...

BACKGROUND: Interindividual differences in outcomes of lipid-lowering therapy are well known. Here, we aimed to characterize how alterations in cellular lipid uptake, storage, and utilization pathways ...