Researchers from Columbia University and the German Cancer Center have found that stellate cells—star-shaped liver cells long known as the main perpetrators in liver fibrosis—have a commanding role in ...

In a mouse model of MASH induced by an FFC diet, integrin β1 (ITGβ1) present in lipotoxic EVs mediates monocyte adhesion to liver sinusoidal endothelial cells, thereby exacerbating hepatic ...

Published today (March 7) in Science Advances, the study is the first to show that ammonia buildup, known as hyperammonaemia, directly harms liver cells. It also details how this damage occurs in ...

Liver injury in Trem-2-/-mice is associated with elevated levels of reactive oxygen species and lipid peroxidation. In line with TREM-2 effects on inflammation and injury, Kupffer cells and hepatic ...