Researchers from Columbia University and the German Cancer Center have found that stellate cells—star-shaped liver cells long known as the main perpetrators in liver fibrosis—have a commanding role in ...

Published today (March 7) in Science Advances, the study is the first to show that ammonia buildup, known as hyperammonaemia, directly harms liver cells. It also details how this damage occurs in ...

Cancer cell-lines in culture can survive and replicate DNA replication after genetic inactivation of individual ORC subunits, ORC1, ORC2 or ORC5. In primary cells, ORC1 was dispensable in the mouse ...

Liver injury in Trem-2-/-mice is associated with elevated levels of reactive oxygen species and lipid peroxidation. In line with TREM-2 effects on inflammation and injury, Kupffer cells and hepatic ...

In a new study published in Developmental Cell, researchers led by Université de Montréal (UdeM) professor Greg FitzHarris show how the early mouse embryo gets rid of the defective or unneeded ...

After blood collection, the animals were executed, and the liver was removed, and the pathological changes of the liver histology were observed ... inflammatory cell infiltration, and Kupffer’s cells ...

Furthermore, the sensitivity of fatty liver transplantation to ischemia-reperfusion injury has been suggested to be related to the production of reactive oxygen species (ROS) and oxidative stress. In ...

How epithelial cell behaviors are coordinately regulated to sculpt tissue architecture is a fundamental question in biology. Kupffer’s vesicle (KV), a transient organ with a fluid-filled lumen, ...