Studies have revealed that apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, is hyperactivated in the liver of NASH patients.

NASH diagnostics consists of CK-18 total, CK-18 cleaved, adiponectin and resistin. NASH diagnostic panel consists of diabetes, gender, BMI, triglyceride and CK-18 total, CK-18 cleaved levels.

You can check out at any time. More info Former Cork All Star hurler Anthony Nash is facing a drink driving charge – less than a week after we revealed he is being prosecuted for alleged ...

Hepatocellular DILI is characterized by inflammation, necrosis, and apoptosis, while cholestatic ... and immune-mediated ...

This review systematically summarizes the regulatory roles of AMPK in lipid metabolism, inflammatory response, cell apoptosis, and fibrosis ... lipotoxicity trigger a cascade of events: damaged ...

In this work, we investigated the effect of hepatocyte PPARα on non-alcoholic fatty liver disease (NAFLD). Design We constructed a novel hepatocyte-specific PPARα knockout (Pparα hep−/−) mouse model.

MicroRNAs (miRNAs) are key contributors to liver diseases progression. This study investigated hepatocyte-abundant miRNAs dysregulated by ALD, its impact on hepatocyte injury and the underlying basis.