The farnesoid X receptor (FXR) is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism.

17 Among the non-receptor PTKs are the Src, JAK (Janus kinase), and FAK (focal adhesion kinase) families. The Src family comprises eight mammalian members (Src, Yes, Fgr, Fyn, Lck, Lyn, Hck, and Blk) ...

Ovulatory dysfunction is the commonest cause of female infertility. Here we show that the co-repressor nuclear-receptor-interacting protein 1 (Nrip1; encoded by the gene Nrip1) is essential for ...

A novel mouse model offers definitive evidence that a single inhibitory receptor family governs the critical natural killer cell functions of licensing and missing-self.

This important study provides solid evidence that glucosylceramide synthase (GlcT), a rate-limiting enzyme for glycosphingolipid (GSL) production, plays a role in the differentiation of intestinal ...

BACKGROUND: Despite the high morbidity and mortality of heart failure with preserved ejection fraction (HFpEF), treatment ...

They found that the GORK channel forms a homotetramer with transmembrane pore (PD) and voltage-sensor (VSD) domains ... GORK K+ channel structure and gating vital to informing stomatal engineering ...

ROCKVILLE, MD – The 36 winners of the annual Student Research Achievement Awards (SRAA) were recognized at the 69 th Biophysical Society Annual Meeting Awards Ceremony on February 17, 2025.

Herpesvirus-encoded microRNAs (v-miRNAs) play a crucial role in modulating host cellular processes to promote viral persistence, immune evasion, and pathogenesis. These v-miRNAs function by targeting ...

The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic function by mediating the homing of progenitor cells in the bone marrow and regulating their mobilization into ...