Ipsen has been given accelerated approval by the FDA for Iqirvo, which becomes the first dual PPAR alpha/delta agonist ... for non-alcoholic steatohepatitis (NASH), a much larger population ...

4+4: Ate. Four plus four is eight, or "ate." (See "ate.") Alpha male: Taken from animal ethology, an alpha male is the dominant member of a group of males, or just a male who is in charge.

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

PPARα is less expressed in the liver of patients with non-alcoholic fatty liver diseases (NAFLD). Several PPAR-targeting molecules, including dual agonists, are currently under investigation for NAFLD ...

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For instance, clinically approved PPAR-γ agonists for liver fibrosis and therapies like Pirfenidone for pulmonary fibrosis offer potential strategies for treating intestinal fibrosis. Although ...