Sprague–Dawley rats 4–5 weeks old and 120–130 g in body weight were used. To produce liver cirrhosis, 1% DMN dissolved in saline was given intraperitoneally at 1 ml per kg body weight for 3 ...

as inhibitors of the transformation of stellate hepatocytes into myofibroblasts, the process responsible for the deposition of collagen fibres leading to cirrhosis. The key mechanism that ensures ...

Metabolic dysfunction-associated fatty liver disease (MAFLD) has become a growing global health concern, affecting millions ...

When the liver is persistently inflamed, its cells (hepatocytes) begin to die and ... Over time, extensive fibrosis leads to cirrhosis, where the liver becomes permanently scarred and hardened.

Metabolic dysfunction-associated steatohepatitis (MASH) significantly increases the risk of liver cirrhosis and hepatocellular ... researchers found that hepatocyte-specific knockout of βKlotho ...

Investigators have found that the gene Asah1 plays a crucial protective role in preventing the progression of nonalcoholic ...

The phase of immune detection/clearance starts when the host immune system tries to clear HBV-infected hepatocytes ... an increased risk of progression to cirrhosis and HCC.

Ready to save your liver? Transcription factors are paving the way for metabolic dysfunction-associated fatty liver disease ...

Hepatic steatosis, often triggered by non-alcoholic fatty liver disease (NAFLD), is a leading cause of liver dysfunction globally, affecting approximately 30% of the population.

These processes, in turn, influence the function of hepatocytes, hepatic stellate ... which may ultimately lead to cirrhosis, is a significant concern in liver disease management.

Hepatic stellate cells reside between the hepatocytes and small blood vessels ... leading to chronic fibrosis or cirrhosis. Liver fibrosis develops from excessive matrix produced by activated ...