Sprague–Dawley rats 4–5 weeks old and 120–130 g in body weight were used. To produce liver cirrhosis, 1% DMN dissolved in saline was given intraperitoneally at 1 ml per kg body weight for 3 ...

When the liver is persistently inflamed, its cells (hepatocytes) begin to die and ... Over time, extensive fibrosis leads to cirrhosis, where the liver becomes permanently scarred and hardened.

as inhibitors of the transformation of stellate hepatocytes into myofibroblasts, the process responsible for the deposition of collagen fibres leading to cirrhosis. The key mechanism that ensures ...

Metabolic dysfunction-associated steatohepatitis (MASH) significantly increases the risk of liver cirrhosis and hepatocellular ... researchers found that hepatocyte-specific knockout of βKlotho ...

Ready to save your liver? Transcription factors are paving the way for metabolic dysfunction-associated fatty liver disease ...

Investigators have found that the gene Asah1 plays a crucial protective role in preventing the progression of nonalcoholic ...

Hepatic steatosis, often triggered by non-alcoholic fatty liver disease (NAFLD), is a leading cause of liver dysfunction globally, affecting approximately 30% of the population.

Less is known about the molecular expression of bile transport mechanism in cholestatic liver diseases in humans. However, with a few exceptions, studies of steady-state mRNA and protein tend to ...

These processes, in turn, influence the function of hepatocytes, hepatic stellate ... which may ultimately lead to cirrhosis, is a significant concern in liver disease management.