Unexpected findings now identify multiple secreted inflammatory cytokines, their cognate receptors ... but triggers apoptosis in cells and xenografted tumours that have already progressed to ...

To determine whether TRA-8 induces hepatocellular toxicity, we examined the susceptibility of normal human hepatocytes to apoptosis induced by either TRA-8 or by soluble TRAIL plus cross-linker.

For example, researchers use a combination of cytokines, including hepatocyte growth factor (HGF), oncostatin M (OSM), epidermal growth factor (EGF), fibroblast growth factor-2 (FGF2), and leukemia ...

Further studies are required to investigate the incidence and role of apoptosis in therapies involving ... of the inflammatory response, a key cytokine in the development of the innate immune ...

[6] Initiation refers to early paracrine-mediated changes in gene expression and phenotype that render the cells responsive to other cytokines ... Kupffer cells, hepatocytes, platelets, and ...