A multi-institutional study led by researchers at UNC Lineberger Comprehensive Cancer Center, the Salk Institute for Biological Studies, and UC San Diego has uncovered new genetic rules that determine ...

Improvements in public health have allowed humankind to survive to older ages than ever before, but, for many people, these ...

Dendritic cells (DCs) are central players in cancer immunity, serving as the primary link between innate and adaptive immune responses. Their functional ...

How do immune cells strike a balance, unleashing rapid attacks against pathogens or cancer, while avoiding damage to healthy cells? Research into an immune kill switch holds potential for controlling ...

The authors would like to express their sincere gratitude to the entire medical and research staff who contributed to the diagnosis, treatment, and follow-up of this case. Special thanks are extended ...

Immunotherapy uses a person’s own immune system to fight cancer. Immune checkpoint inhibitors are one class of immunotherapy that block specific proteins from slowing the immune response. As a result, ...

During infections, the immune system needs to distinguish foreign molecules from invading bacteria and viruses from molecules that are made by cells of the body. If it can’t, the immune system can ...

Checkpoint blockade has transformed cancer immunotherapy, but many patients do not respond clinically. In this work, we longitudinally profile a cohort of patients with locally advanced skin cancers ...

A new study has revealed that a special group of cells in the intestines tamp down the immune responses caused by exposure to food proteins. Called 'tolerogenic dendritic cells,' these cells enable ...

Introduction: MYD88 (myeloid differentiation primary response 88) is a key adaptor protein mediate immune responses, primarily through Toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R) ...