Mirum Pharmaceuticals, Inc. , a leading rare disease company, today announced that Health Canada has authorized the tablet formulation of LIVMARLI® (maralixibat) for the treatment of cholestatic ...

The reported increase of the early onset of multiple types of cancer (defined as a cancer diagnosis prior to 50 years of age) ...

Primary biliary cholangitis (PBC) is a rare chronic autoimmune cholangiopathy that mainly affects middle-aged women, ...

Mental health conditions such as alcohol use disorder and PTSD could significantly increase risk for liver cancer among ...

—Recurrent primary biliary cholangitis (rPBC) occurs in a significant number of patients following liver transplantation for PBC. Various immunosuppressive therapies and ursodeoxycholic acid treatment ...

Intrahepatic biliary stone disease is a difficult condition to treat, due to anatomical complexity of biliary tract, association with colestasis, and high recurrence rates, with potential short- and ...

1 Guangdong Medical University, Zhanjiang, Guangdong, China 2 Department of Hepatobiliary Surgery, Zhongshan City People’s Hospital, Zhongshan, Guangdong, China Background: Laparoscopic ...

Livdelzi improved or maintained liver stiffness in up to 85% of PBC patients, with significant reductions in high-risk groups. As a second-line therapy, Livdelzi showed efficacy in reducing alkaline ...

BACKGROUND: Bile duct injury (BDI) causes significant sequelae for the patient in terms of morbidity, mortality, and long-term quality of life, and should be managed in centers with expertise.

The heterogeneity of iCCA poses significant challenges to both targeted therapy and immunotherapy, necessitating in-depth exploration at the molecular and subtyping levels. Investigating genetic ...

Intersectional disparities in mortality of laryngeal cancer: A retrospective analysis. Recent trends in SEER Age-Adjusted incidence rates, 2017-2021. Group Average Annual Percent Change (AAPC) Lower ...

- 28-week data from the Phase 2b VANTAGE PBC study highlights statistically significant improvements in pruritus and numeric improvements in fatigue, the two most burdensome symptoms of PBC - Seventy ...