Cancer cell-lines in culture can survive and replicate DNA replication after genetic inactivation of individual ORC subunits, ORC1, ORC2 or ORC5. In primary cells, ORC1 was dispensable in the mouse ...

The same genes could hold the key to regenerating cells in the ear and eye, according to a new mouse study from the USC Stem ...

The liver is a vital organ, crucial to digestion, metabolism and the elimination of toxins. It has a unique ability, ...

High levels of ammonia kill liver cells by damaging the mitochondria that power the cells. But this can be prevented using an existing drug due to start clinical trials, finds a new study in mice.

Liver disease patients waiting for a transplant have been offered fresh hope. A new mechanism for rapid liver regeneration ...

The earliest changes in stellate cells are likely to result from paracrine stimulation by all neighboring cell types, including sinusoidal endothelium, Kupffer ... cell type in liver, are a ...

This review provides a detailed examination of experimental mouse ... liver damage, characterized by the deposition of extracellular matrix (ECM) by activated hepatic stellate cells (HSCs) and ...

Primary liver cancer is cancer that started in the liver. There are 5 main types. The type depends on the type of cell that the cancer started in. Primary liver cancer is different to cancer that ...

Manor and his team found that these receptors are expressed in the mouse cochlea as early as one month after birth ... or left untreated and labeled the synapses between cochlear hair cells and ...

Enhancing cell-specific targeting of conjugated NPs in the liver has two major hurdles: 1) avoiding accumulation of NPs in the liver resident macrophages known as Kupffer cells, which are optimized to ...