'Inheritance through homology' is the most common and generally more accessible approach to function prediction, but orthology should be established where possible to improve confidence in predictions ...

In industrial applications, controlling relays, servos, solenoids, and the like isn’t just a matter of wiring in an Arduino and plugging in some code. No, for reliable operation you’ll need a PLC – a ...

In this important work, the authors present a new transformer-based neural network designed to isolate and quantify higher-order epistasis in protein sequences. They provide solid evidence that higher ...

Metalloproteins perform a wide range of biological and chemical functions, but elucidating their sequence–function relationships is difficult due to their complex folding pathways and various ...

The final, formatted version of the article will be published soon. Resistance to programmed cell death is a defining hallmark of cancer and a persistent barrier to successful therapy. Dual-function ...

We thank Dr. Jianzhi Zhang, Dr. Xionglei He, Dr. Weiwei Zhai, Shanshan Chen, Han Liu, Tianhan Wang, and three anonymous reviewers for valuable comments. This work was supported by the Strategic ...

Edited by James Giovannoni, Boyce Thompson Institute for Plant Research, Ithaca, NY; received November 3, 2024; accepted January 9, 2025 ...