The final, formatted version of the article will be published soon. Resistance to programmed cell death is a defining hallmark of cancer and a persistent barrier to successful therapy. Dual-function ...

Edited by James Giovannoni, Boyce Thompson Institute for Plant Research, Ithaca, NY; received November 3, 2024; accepted January 9, 2025 ...

Metalloproteins perform a wide range of biological and chemical functions, but elucidating their sequence–function relationships is difficult due to their complex folding pathways and various ...

In this important work, the authors present a new transformer-based neural network designed to isolate and quantify higher-order epistasis in protein sequences. They provide solid evidence that higher ...

The authors present an approach that uses the transformer architecture to model epistasis in deep mutational scanning datasets. This is an original and very interesting idea. Applying the approach to ...

We thank Dr. Jianzhi Zhang, Dr. Xionglei He, Dr. Weiwei Zhai, Shanshan Chen, Han Liu, Tianhan Wang, and three anonymous reviewers for valuable comments. This work was supported by the Strategic ...